Conditionally Controlling Human TLR2 Activity via Trans-Cyclooctene Caged Ligands
نویسندگان
چکیده
منابع مشابه
The Living ROMP of trans-Cyclooctene.
The living ring-opening metathesis polymerization (ROMP) of trans-cyclooctene (tCO) was investigated. ROMP of tCO in the presence of PPh(3) in THF leads to the formation of narrowly dispersed polycyclooctene (PCO). The presence of PPh(3) as an additive and the use of THF as a solvent were demonstrated to be necessary to suppress competing secondary metathesis processes in the ROMP of tCO. Under...
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The development of fluorogenic reactions which lead to the formation of fluorescent products from two nonfluorescent starting materials is highly desirable, but challenging. Reported herein is a new concept of fluorescent product formation upon the inverse electron-demand Diels-Alder reaction of 1,2,4,5-tetrazines with particular trans-cyclooctene (TCO) isomers. In sharp contrast to known fluor...
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Post-synthesis DNA modification is a very useful method for DNA functionalization. This is achieved by using a modified NTP, which has a handle for further modifications, replacing the corresponding natural NTP in polymerase-catalyzed DNA synthesis. Subsequently, the handle can be used for further functionalization after PCR, preferably through a very fast reaction. Herein we describe polymeras...
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2020
ISSN: 1043-1802,1520-4812
DOI: 10.1021/acs.bioconjchem.0c00237